High Affinity Nav Channel Binder with Specific Conjugation Site Derived from Scorpion Toxin with Attenuated Toxicity
نویسندگان
چکیده
منابع مشابه
The Paradox of Scorpion Toxin Interactions with Portable Nav Receptors
Scorpion venom is rich in proteinaceous toxins that affect excitability by impeding ion channel gating. Channel blockers interact with the external region of the pore and obstruct ion conductance, whereas channel modifiers interact with the voltage sensor module hindering the activation or inactivation processes [1-3]. Scorpion toxin modifiers of voltage-gated sodium channels (Navs) are divided...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.664